diff --git a/python/cdp/evm_local_account.py b/python/cdp/evm_local_account.py
index 2c1cb0d0d..be6fdb0aa 100644
--- a/python/cdp/evm_local_account.py
+++ b/python/cdp/evm_local_account.py
@@ -1,7 +1,7 @@
 import asyncio
+from concurrent.futures import ThreadPoolExecutor
 from typing import Any
 
-import nest_asyncio
 from eth_account.datastructures import SignedMessage, SignedTransaction
 from eth_account.messages import SignableMessage, _hash_eip191_message, encode_typed_data
 from eth_account.signers.base import BaseAccount
@@ -11,35 +11,28 @@
 from cdp.errors import UserInputValidationError
 from cdp.evm_server_account import EvmServerAccount
 
-# Apply nest-asyncio to allow nested event loops, but only if compatible
-try:
-    nest_asyncio.apply()
-except ValueError as e:
-    # If nest_asyncio can't patch the loop (e.g., uvloop), silently continue
-    # This commonly happens when uvloop is installed and running
-    if "Can't patch loop" in str(e):
-        pass
-    else:
-        # Re-raise other ValueError exceptions
-        raise
-
 
 def _run_async(coroutine):
     """Run an async coroutine synchronously.
 
+    If no event loop is running, asyncio.run is used directly.
+    If an event loop is already running, the coroutine is executed
+    in a background thread to avoid nested loop issues.
+
     Args:
-        coroutine: The coroutine to run
+        coroutine: The coroutine to run.
 
     Returns:
-        Any: The result of the coroutine
+        Any: The result of the coroutine.
 
     """
     try:
-        loop = asyncio.get_event_loop()
+        asyncio.get_running_loop()
     except RuntimeError:
-        loop = asyncio.new_event_loop()
-        asyncio.set_event_loop(loop)
-    return loop.run_until_complete(coroutine)
+        return asyncio.run(coroutine)
+
+    with ThreadPoolExecutor(max_workers=1) as executor:
+        return executor.submit(asyncio.run, coroutine).result()
 
 
 class EvmLocalAccount(BaseAccount):
diff --git a/python/changelog.d/591.bugfix.md b/python/changelog.d/591.bugfix.md
new file mode 100644
index 000000000..822e02625
--- /dev/null
+++ b/python/changelog.d/591.bugfix.md
@@ -0,0 +1 @@
+Removed `nest-asyncio` dependency and replaced it with a thread-safe fallback in `EvmLocalAccount`, restoring compatibility with Python 3.12+ and modern uvicorn.
diff --git a/python/pyproject.toml b/python/pyproject.toml
index b45386941..86826271c 100644
--- a/python/pyproject.toml
+++ b/python/pyproject.toml
@@ -17,7 +17,6 @@ dependencies = [
     "web3>=7.6.0,<=7.10.0",
     "solana>=0.36.6",
     "solders>=0.26.0",
-    "nest-asyncio>=1.6.0,<2",
     "base58>=2.1.1",
 ]
 
diff --git a/python/uv.lock b/python/uv.lock
index 93bd95439..e439af70c 100644
--- a/python/uv.lock
+++ b/python/uv.lock
@@ -1,5 +1,5 @@
 version = 1
-revision = 2
+revision = 3
 requires-python = ">=3.10"
 resolution-markers = [
     "python_full_version >= '3.11'",
@@ -310,7 +310,6 @@ dependencies = [
     { name = "aiohttp-retry" },
     { name = "base58" },
     { name = "cryptography" },
-    { name = "nest-asyncio" },
     { name = "pydantic" },
     { name = "pyjwt" },
     { name = "python-dateutil" },
@@ -345,7 +344,6 @@ requires-dist = [
     { name = "base58", specifier = ">=2.1.1" },
     { name = "cryptography", specifier = ">=42.0.0" },
     { name = "myst-parser", marker = "extra == 'dev'", specifier = ">=4.0.1" },
-    { name = "nest-asyncio", specifier = ">=1.6.0,<2" },
     { name = "pydantic", specifier = ">=2.10.3" },
     { name = "pyjwt", specifier = ">=2.10.1" },
     { name = "pytest", marker = "extra == 'dev'", specifier = ">=8.0.0" },
@@ -1307,15 +1305,6 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/5f/df/76d0321c3797b54b60fef9ec3bd6f4cfd124b9e422182156a1dd418722cf/myst_parser-4.0.1-py3-none-any.whl", hash = "sha256:9134e88959ec3b5780aedf8a99680ea242869d012e8821db3126d427edc9c95d", size = 84579, upload-time = "2025-02-12T10:53:02.078Z" },
 ]
 
-[[package]]
-name = "nest-asyncio"
-version = "1.6.0"
-source = { registry = "https://pypi.org/simple" }
-sdist = { url = "https://files.pythonhosted.org/packages/83/f8/51569ac65d696c8ecbee95938f89d4abf00f47d58d48f6fbabfe8f0baefe/nest_asyncio-1.6.0.tar.gz", hash = "sha256:6f172d5449aca15afd6c646851f4e31e02c598d553a667e38cafa997cfec55fe", size = 7418, upload-time = "2024-01-21T14:25:19.227Z" }
-wheels = [
-    { url = "https://files.pythonhosted.org/packages/a0/c4/c2971a3ba4c6103a3d10c4b0f24f461ddc027f0f09763220cf35ca1401b3/nest_asyncio-1.6.0-py3-none-any.whl", hash = "sha256:87af6efd6b5e897c81050477ef65c62e2b2f35d51703cae01aff2905b1852e1c", size = 5195, upload-time = "2024-01-21T14:25:17.223Z" },
-]
-
 [[package]]
 name = "packaging"
 version = "24.2"